Authors: Berényi S, Csutorás C, Sipos A The most practical synthetic routes to the preparation of as important pharmaceuticals as oxycodone, naloxone, naltrexone, nalbuphine and buprenorphine have utilized the alkaloid, thebaine, as a starting material. This review intends to focus on chemical transformations of morphinans which resulted in morphinandiene derivatives with well-established and novel pharmacological potencies. These chemical transformations were mainly associated with the formation and substitution of the unique diene structure of the ring C of the morphinan backbone. PMID: 19548872 [PubMed - as supplied by publisher] (Source: Current Medicinal Chemistry)MedWorm Sponsor Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
(Source: Clinical Chemistry)
(Source: Clinical Chemistry)
The Onion: Anonymous Hero Donates Hospital 200 Human Kidneys
I had to share this one
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