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This study examines trends in the reported abuse of two sublingual buprenorphine products, Subutex and Suboxone, in the United States. Quarterly counts of abuse cases were obtained from 18 regional poison control centers (PCCS) for 2003-2005. Seventy-seven… (Source: SafetyLit: All (Unduplicated)) MedWorm Sponsored Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.
Addiction, Volume 102, Issue 12, Page 1899-1907, December 2007. ABSTRACT Aims To compare the effectiveness and cost-effectiveness of unobserved versus observed dosing of patients seeking treatment of heroin dependence. Design Randomized controlled trial and cost-effectiveness analysis. Setting Specialist out-… (Source: Addiction)
Related Articles An evaluation of the genotoxicity of the antitussive drug Dextromethorphan. Regul Toxicol Pharmacol. 2007 Nov 17; Authors: Aardema MJ, Robison SH, Gatehouse D, Johnston G Dextromethorphan (DMP) is an effective and widely used antitussive drug. While DMP has over a 50 year safe-marketing history, the only available genotoxicity data was an unpublished, negative Ames assay (Roche). Lack of a complete genotoxicity profile on DMP, specifically covering the chromosomal damage endpoint, prompted a regulatory request for an in vitro chromosome aberration assay. In accordance with EC and CPMP Guidance, we evaluated data for a number of chemicals with a structural relationship to DMP. DMP contains no structural alerts for genotoxicity or carcinogenicity using the Deductive Estimation of Risk from Existing Knowledge (DEREK) software tool, confirming the negative results obtained in the existing Ames assay. This is also consistent with the mostly negative genotoxicity and carcinogenicity data available on structurally related chemicals including morphine, codeine, nalbuphine, buprenorphine, naloxone, hydromorphone, levorphanol, and oxycodone. A state-of-the-science, in vitro chromosome aberration assay was also conducted, which demonstrated a lack of genotoxicity for DMP. The overall weight of evidence for DMP and its structural analogues, supports the conclusion that this class of phenanthrene-based chemicals, and DMP, in particular, are not genotoxic in vitro or in vivo, and do not represent a carcinogenic risk to patients. PMID: 18160193 [PubMed - as supplied by publisher] (Source: Regulatory Toxicology and Pharmacology : RTP)
Opiate addiction is a growing problem. Prescription drugs like Vicodin, Oxycontin, and Fentanyl are being abused at an alarming rate. The HIV population has its share of substance abuse issues… (Source: About AIDS / HIV)